abstract：:Renewing interest in immune aspects of schizophrenia and new findings about the brain-fat axis encourage us to discuss the possible role of interleukin-6 (IL-6) in schizophrenia. Previously, it was suggested that a primary alteration of the innate immune system may be relevant in schizophrenia. Functional dichotomy of...

journal_title：Frontiers in psychiatry

authors： Borovcanin MM,Jovanovic I,Radosavljevic G,Pantic J,Minic Janicijevic S,Arsenijevic N,Lukic ML

更新日期：2017-11-06 00:00:00

abstract：Background:High rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR individuals in non-c...

journal_title：Frontiers in psychiatry

authors： Shi J,Wang L,Yao Y,Su N,Zhan C,Mao Z,Zhao X

更新日期：2017-10-23 00:00:00

abstract：:New models of care aimed at reinforcing the outpatient sector have been introduced in Germany over the last few years. Initially, a subscription-based model ("integrated care") was introduced in 2012 in the Immanuel Klinik Rüdersdorf, wherein patients had to actively subscribe to the integrated care program. This inte...

journal_title：Frontiers in psychiatry

authors： Wullschleger A,Wosniok W,Timm J,Heinze M

更新日期：2017-10-05 00:00:00

abstract：BACKGROUND:Research has demonstrated a reduction in olfactory functioning in patients with schizophrenia. This research has led to examination of olfactory functioning in other mental disorders, such as depression. There is a great deal of variation in the results generated from such research, and it remains unclear as...

journal_title：Frontiers in psychiatry

authors： Taalman H,Wallace C,Milev R

更新日期：2017-09-28 00:00:00

abstract：:Pharmacological approaches to cognitive enhancement have received considerable attention but have not had considerable success in improving their cognitive and functional targets. Other intervention strategies, such as cognitive remediation therapy (CRT), have been shown to enhance cognitive performance but have not b...

journal_title：Frontiers in psychiatry

authors： Harvey PD,Sand M

更新日期：2017-09-25 00:00:00

abstract：:Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, di...

journal_title：Frontiers in psychiatry

authors： Galvão-Coelho NL,Galvão ACM,da Silva FS,de Sousa MBC

更新日期：2017-09-21 00:00:00

abstract：:A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects. These drugs change the mental state and/or the behavioral performance of an individual and can be instrumentalized for various purposes. After the emergen...

journal_title：Frontiers in psychiatry

authors： Hassan Z,Bosch OG,Singh D,Narayanan S,Kasinather BV,Seifritz E,Kornhuber J,Quednow BB,Müller CP

更新日期：2017-08-18 00:00:00

abstract：:Betel quid (BQ) is one of the most commonly consumed psychoactive substances. It has been suggested to be associated with various health issues, especially oral cancer. Evidence also points to possible decreased cognitive functions after long-term BQ chewing, such as attention and inhibition control. The present study...

journal_title：Frontiers in psychiatry

authors： Yuan F,Kong L,Zhu X,Jiang C,Fang C,Liao W

更新日期：2017-08-03 00:00:00

abstract：:There is an increasing awareness that autoimmune diseases can present with neuropsychiatric manifestations. We present the case of a 17-year-old female requiring psychiatric hospitalization for obsessive-compulsive disorder and major depressive disorder with mixed affective features, who was subsequently diagnosed wit...

journal_title：Frontiers in psychiatry

authors： Ong LTC,Galambos G,Brown DA

更新日期：2017-07-11 00:00:00

abstract：:Impaired manual dexterity is commonly observed in schizophrenia. However, a quantitative description of key sensorimotor components contributing to impaired dexterity is lacking. Whether the key components of dexterity are differentially affected and how they relate to clinical characteristics also remains unclear. We...

journal_title：Frontiers in psychiatry

authors： Térémetz M,Carment L,Brénugat-Herne L,Croca M,Bleton JP,Krebs MO,Maier MA,Amado I,Lindberg PG

更新日期：2017-07-10 00:00:00

abstract：BACKGROUND:Females are twice as likely as males to experience depression. Recent findings indicate a relationship linking inflammation with depression. Whether the higher prevalence of depression in women is sex-specific or if inflammation contributes to a higher prevalence of depression in females is unclear. Thus, th...

journal_title：Frontiers in psychiatry

authors： Birur B,Amrock EM,Shelton RC,Li L

更新日期：2017-06-16 00:00:00

abstract：:Major depressive disorder (MDD) is the most common non-motor manifestation of Parkinson's disease (PD) affecting 50% of patients. However, little is known about the cognitive correlates of MDD in PD. Using a computer-based cognitive task that dissociates learning from positive and negative feedback, we tested four gro...

journal_title：Frontiers in psychiatry

authors： Herzallah MM,Khdour HY,Taha AB,Elmashala AM,Mousa HN,Taha MB,Ghanim Z,Sehwail MM,Misk AJ,Balsdon T,Moustafa AA,Myers CE,Gluck MA

更新日期：2017-06-12 00:00:00

abstract：INTRODUCTION:Ruminative (abstract verbal) processing during recall of aversive autobiographical memories may serve to dampen their short-term affective impact. Experimental studies indeed demonstrate that verbal processing of non-autobiographical material and positive autobiographical memories evokes weaker affective r...

journal_title：Frontiers in psychiatry

authors： Slofstra C,Eisma MC,Holmes EA,Bockting CLH,Nauta MH

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:Schizophreniform syndromes can be divided into primary forms from polygenic causes or secondary forms due to immunological, epileptiform, monogenic, or degenerative causes. Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a secondary immunological form associated with incre...

journal_title：Frontiers in psychiatry

authors： Endres D,Perlov E,Riering AN,Maier V,Stich O,Dersch R,Venhoff N,Erny D,Mader I,Tebartz van Elst L

更新日期：2017-04-21 00:00:00

abstract：:In this short review, we want to summarize the current findings on the role of vitamin-D in multiple sclerosis (MS), schizophrenia, and autism. Many studies have highlighted hypovitaminosis-D as a potential environmental risk factor for a variety of conditions such as MS, asthma, cardiovascular disease, and, more rece...

journal_title：Frontiers in psychiatry

authors： Kočovská E,Gaughran F,Krivoy A,Meier UC

更新日期：2017-03-27 00:00:00

abstract：:Pathological impulsivity is encountered in a broad range of psychiatric conditions and is thought to be a risk factor for aggression directed against oneself or others. Recently, a strong association was found between impulsivity and obesity which may explain the high prevalence of metabolic disorders in individuals w...

journal_title：Frontiers in psychiatry

authors： Sfera A,Osorio C,Inderias LA,Parker V,Price AI,Cummings M

更新日期：2017-02-13 00:00:00

abstract：AIM:In efforts to develop reliable methods to detect the likelihood of impending suicidal behaviors, we have proposed the following. OBJECTIVE:To gain a deeper understanding of the state of suicide risk by determining the combination of variables that distinguishes between groups with and without suicide risk. METHOD...

journal_title：Frontiers in psychiatry

authors： Morales S,Barros J,Echávarri O,García F,Osses A,Moya C,Maino MP,Fischman R,Núñez C,Szmulewicz T,Tomicic A

更新日期：2017-02-02 00:00:00

abstract：:Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with ref...

journal_title：Frontiers in psychiatry

authors： Raymond JG,Steele JD,Seriès P

更新日期：2017-01-23 00:00:00

abstract：:Studies have shown a direct link between memory for emotionally salient experiences and false memories. In particular, emotionally arousing material of negative and positive valence enhanced reality monitoring compared to neutral material since emotional stimuli can be encoded with more contextual details and thereby ...

journal_title：Frontiers in psychiatry

authors： Fairfield B,Altamura M,Padalino FA,Balzotti A,Di Domenico A,Mammarella N

更新日期：2016-11-30 00:00:00

abstract：:Previous work has demonstrated that goal-directed control of alcohol-seeking and other drug-related behaviors is reduced following extended self-administration and drug exposure. Here, we examined how the magnitude of stimulus influences on responding changes across similar training and drug exposure. Rats self-admini...

journal_title：Frontiers in psychiatry

authors： Corbit LH,Janak PH

更新日期：2016-10-10 00:00:00

abstract：BACKGROUND:Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder affecting children, adolescents, and adults. Its etiology is not well understood, but it is increasingly believed to result from diverse pathophysiologies that affect the structure and function of specific brain circui...

journal_title：Frontiers in psychiatry

authors： Khadka S,Pearlson GD,Calhoun VD,Liu J,Gelernter J,Bessette KL,Stevens MC

更新日期：2016-07-25 00:00:00

abstract：:In the field of mental health, games and computerized games present questions about paradoxes, evidences, and challenges. This perspective article offers perspectives and personal opinion about these questions, evidences, and challenges with an objective of presenting several ideas and issues in this rapidly developin...

journal_title：Frontiers in psychiatry

authors： Desseilles M

更新日期：2016-07-04 00:00:00

abstract：:The graph theoretical analysis of structural magnetic resonance imaging (MRI) data has received a great deal of interest in recent years to characterize the organizational principles of brain networks and their alterations in psychiatric disorders, such as schizophrenia. However, the characterization of networks in cl...

journal_title：Frontiers in psychiatry

authors： Edwin Thanarajah S,Han CE,Rotarska-Jagiela A,Singer W,Deichmann R,Maurer K,Kaiser M,Uhlhaas PJ

更新日期：2016-06-30 00:00:00

abstract：BACKGROUND:The project "Quality Assurance in Ambulatory Psychotherapy in Bavaria" (QS-PSY-BAY) focuses on the quality assurance of outpatient psychotherapy (OPT) in Germany in terms of symptom reduction and cost reduction under naturalistic conditions. In this study, we examined the effectiveness of psychotherapy in te...

journal_title：Frontiers in psychiatry

authors： Altmann U,Zimmermann A,Kirchmann HA,Kramer D,Fembacher A,Bruckmayer E,Pfaffinger I,von Heymann F,Auch E,Steyer R,Strauss BM

更新日期：2016-06-13 00:00:00

abstract：:Third-generation neuroimaging research has been enriched by advances in magnetic resonance spectroscopy (MRS) measuring the concentration of important neurotrasmitters, such as the inhibitory amino acid GABA. Here, we performed a systematic mini-review on brain MRS studies measuring GABA concentration in patients affe...

journal_title：Frontiers in psychiatry

authors： Chiapponi C,Piras F,Piras F,Caltagirone C,Spalletta G

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Several lines of evidence implicate dysfunctional neuronal plasticity in the pathophysiology of schizophrenia (SCZ). Aberrant glutamatergic and gamma amino--butyric acid neurotransmission are thought to underlie core cognitive deficits and negative symptoms of SCZ. Non-invasive brain stimulation (NIBS) allow...

journal_title：Frontiers in psychiatry

authors： Bhandari A,Voineskos D,Daskalakis ZJ,Rajji TK,Blumberger DM

更新日期：2016-03-29 00:00:00

abstract：:It has been proposed that compulsive drug seeking reflects an underlying dysregulation in adaptive behavior that favors habitual (automatic and inflexible) over goal-directed (deliberative and highly flexible) action selection. Rodent studies have established that repeated exposure to cocaine or amphetamine facilitate...

journal_title：Frontiers in psychiatry

authors： Halbout B,Liu AT,Ostlund SB

更新日期：2016-03-21 00:00:00

abstract：BACKGROUND:Identifying objective and accurate markers of cocaine dependence (CD) can innovate its prevention and treatment. Existing evidence suggests that CD is characterized by a wide range of cognitive deficits, most notably by increased impulsivity. Impulsivity is multidimensional and it is unclear which of its var...

journal_title：Frontiers in psychiatry

authors： Ahn WY,Ramesh D,Moeller FG,Vassileva J

更新日期：2016-03-10 00:00:00

abstract：:The view that anatomically distinct memory systems differentially contribute to the development of drug addiction and relapse has received extensive support. The present brief review revisits this hypothesis as it was originally proposed 20 years ago (1) and highlights several recent developments. Extensive research e...

journal_title：Frontiers in psychiatry

authors： Goodman J,Packard MG

更新日期：2016-02-25 00:00:00

abstract：:In its initial formulation, the concept of basic symptoms (BSs) integrated findings on the early symptomatic course of schizophrenia and first in vivo evidence of accompanying brain aberrations. It argued that the subtle subclinical disturbances in mental processes described as BSs were the most direct self-experience...

journal_title：Frontiers in psychiatry

authors： Schultze-Lutter F,Debbané M,Theodoridou A,Wood SJ,Raballo A,Michel C,Schmidt SJ,Kindler J,Ruhrmann S,Uhlhaas PJ

更新日期：2016-01-28 00:00:00

abstract：:Timing is a fundamental and highly conserved mammalian capability, yet the underlying neural mechanisms are widely debated. Ramping activity of single neurons that gradually increase or decrease activity to encode the passage of time has been speculated to predict a behaviorally relevant temporal event. Cue-evoked low...

journal_title：Frontiers in psychiatry

authors： Parker KL

更新日期：2016-01-18 00:00:00

abstract：:There is accruing evidence of cerebellar abnormalities in schizophrenia. The theory of cognitive dysmetria considers cerebellar dysfunction a key component of schizophrenia. Delay eyeblink conditioning (EBC), a cerebellar-dependent translational probe, is a behavioral index of cerebellar integrity. The circuitry under...

journal_title：Frontiers in psychiatry

authors： Kent JS,Bolbecker AR,O'Donnell BF,Hetrick WP

更新日期：2015-12-18 00:00:00

abstract：:Childhood maltreatment (CM), including abuse and neglect, is a crucial factor that distorts child development. CM is associated with alterations in numerous brain regions, and may be associated with hormonal dysregulation. This study aimed to investigate differences in secretion patterns of cortisol (CT) and oxytocin ...

journal_title：Frontiers in psychiatry

authors： Mizushima SG,Fujisawa TX,Takiguchi S,Kumazaki H,Tanaka S,Tomoda A

更新日期：2015-12-11 00:00:00

abstract：:In the brain of female mammals, including humans, a number of physiological and behavioral changes occur as a result of sex hormone exposure. Estradiol and progesterone regulate several brain functions, including learning and memory. Sex hormones contribute to shape the central nervous system by modulating the formati...

journal_title：Frontiers in psychiatry

authors： Hansberg-Pastor V,González-Arenas A,Piña-Medina AG,Camacho-Arroyo I

更新日期：2015-11-20 00:00:00

abstract：:Very-brief, web-based alcohol interventions have great potential due to their convenience, ease of dissemination, and college students' stated preference for this intervention modality. To address the efficacy of these interventions, we conducted a review of the literature to identify randomized controlled trials (RCT...

journal_title：Frontiers in psychiatry

authors： Leeman RF,Perez E,Nogueira C,DeMartini KS

更新日期：2015-09-28 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is a common cause of physical, psychological, and cognitive impairment, but many current treatments for TBI are ineffective or produce adverse side effects. Non-invasive methods of brain stimulation could help ameliorate some common trauma-induced symptoms. OBJECTIVE:This review...

journal_title：Frontiers in psychiatry

authors： Dhaliwal SK,Meek BP,Modirrousta MM

更新日期：2015-08-26 00:00:00

abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) is known to modulate spontaneous neural network excitability. The cognitive improvement observed in previous trials raises the potential of this technique as a possible therapeutic tool for use in attention-deficit/hyperactivity disorder (ADHD) population. Howev...

journal_title：Frontiers in psychiatry

authors： Cosmo C,Ferreira C,Miranda JG,do Rosário RS,Baptista AF,Montoya P,de Sena EP

更新日期：2015-08-04 00:00:00

abstract：:This hypothesis and theory paper presents a pragmatic framework to help bridge the clinical presentation and neuroscience of intrusive memories following psychological trauma. Intrusive memories are a hallmark symptom of post-traumatic stress disorder (PTSD). However, key questions, including those involving etiology,...

journal_title：Frontiers in psychiatry

authors： Clark IA,Mackay CE

更新日期：2015-07-22 00:00:00

abstract：:Mental imagery, seeing with the mind's eyes, can induce stronger positive as well as negative affect compared to verbal processing. Given this emotion-amplifying effect, it appears likely that mental images play an important role in affective disorders. According to the subcomponents model of depression, depressed moo...

journal_title：Frontiers in psychiatry

authors： Görgen SM,Joormann J,Hiller W,Witthöft M

更新日期：2015-07-07 00:00:00

abstract：:The prevalence of alcohol abuse among patients treated in accident and emergency departments (A&E) is considered as substantial. This paper is a narrative review of studies investigating the effectiveness of brief interventions (BI) for hazardous and harmful alcohol consumption in A&E. A&E departments in hospitals (an...

journal_title：Frontiers in psychiatry

authors： Wojnar M,Jakubczyk A

更新日期：2014-11-03 00:00:00